Eccrine angiomatous hamartoma is a lymphatic proliferation.

BACKGROUND

Eccrine angiomatous hamartoma (EAH) is recognized as a vascular hamartoma composed of abnormal proliferation of blood vessels and eccrine glands.

OBJECTIVE

We sought to investigate the immunohistochemical results of D2-40 and Prox1 in EAH in order to gain further insight into its histogenesis.

MATERIALS AND

METHODS

We collected 21 cases of EAH diagnosed in a dermatology department. Immunohistochemical staining of D2-40 and Prox1 was performed on all cases.

RESULTS

Prox1 was universally positive in the endothelial cells of proliferated vessels in all cases. D2-40 was universally positive in the endothelial cells of proliferated vessels in 3 cases, focally positive in 18 cases.

CONCLUSION

EAH is a lymphatic proliferation and therefore we suggest the name of eccrine lymphangiomatous hamartoma.