Effect of route of feeding on the incidence of septic complications in critically ill patients.

The increased risk of septic complications accompanying severe illness and injury is compounded by the presence of malnutrition. Total parenteral nutrition (TPN) has been used extensively to prevent or rectify this problem. Although enteral nutrition is frequently more difficult to administer, a growing body of laboratory and clinical research shows a significant reduction in the incidence of secondary infection with its use. The mechanism proposed is that the enteral route helps maintain the gut barrier, decreasing passage of bacteria and other toxins. Translocation of these products has been implicated as a cause of nosocomial infection and organ failure. Therefore, when possible, the use of the enteral route of nutrition should be part of the overall approach to the care of the critically ill or injured patient.