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The association between body roundness index and lumbar marrow fat content in postmenopausal women.
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Luo Peng, Miao Zeyang, Guo Mengyao, Qin Lingdi, Xu Run, Lu Li, Wang Ying, Li Guanwu
Аннотация
OBJECTIVE: To investigate the relationship between body roundness index (BRI) and lumbar marrow proton density fat fraction (PDFF) in postmenopausal women, with emphasis on potential nonlinear associations.
METHODS: In this retrospective cross-sectional study of 186 postmenopausal women, lumbar PDFF was quantified using T2-corrected magnetic resonance spectroscopy (L3 vertebra), and bone mineral density (BMD) was assessed via dual-energy X-ray absorptiometry. Multivariable-adjusted linear regression and nonlinear analyses (smooth curve fitting, two-segment linear models) were employed to evaluate BRI-PDFF relationships, adjusting for age, menopause duration, physical activity, and BMD.
RESULTS: Both BRI and lumbar BMD exhibited significant inverse correlations with PDFF (BRI: r = -0.513; BMD: r = -0.462; both P < 0.001). Higher BRI quartiles were associated with elevated BMD at total hip, femoral neck, and lumbar spine (P < 0.05, Q4 vs. Q1-Q3) and a progressive reduction in adjusted PDFF (Ptrend < 0.05). Linear regression confirmed dose-dependent inverse associations between BRI (continuous/quartile) and PDFF (adjusted β = -1.870 to -11.098, P < 0.05 for Q3-Q4 vs. Q1; Ptrend < 0.001). Nonlinear analysis identified a threshold at BRI = 2.58: below this point, BRI strongly predicted PDFF reduction (β = -26.048, P < 0.001), whereas the association attenuated above it (β = -1.086, P = 0.024).
CONCLUSIONS: Increased BRI independently correlates with reduced marrow adiposity in postmenopausal women, with a nonlinear threshold effect (BRI = 2.58) suggesting distinct biological mechanisms at lower versus higher adiposity levels. These findings highlight BRI as a potential biomarker for marrow fat dynamics and a target for metabolic bone disease interventions.
METHODS: In this retrospective cross-sectional study of 186 postmenopausal women, lumbar PDFF was quantified using T2-corrected magnetic resonance spectroscopy (L3 vertebra), and bone mineral density (BMD) was assessed via dual-energy X-ray absorptiometry. Multivariable-adjusted linear regression and nonlinear analyses (smooth curve fitting, two-segment linear models) were employed to evaluate BRI-PDFF relationships, adjusting for age, menopause duration, physical activity, and BMD.
RESULTS: Both BRI and lumbar BMD exhibited significant inverse correlations with PDFF (BRI: r = -0.513; BMD: r = -0.462; both P < 0.001). Higher BRI quartiles were associated with elevated BMD at total hip, femoral neck, and lumbar spine (P < 0.05, Q4 vs. Q1-Q3) and a progressive reduction in adjusted PDFF (Ptrend < 0.05). Linear regression confirmed dose-dependent inverse associations between BRI (continuous/quartile) and PDFF (adjusted β = -1.870 to -11.098, P < 0.05 for Q3-Q4 vs. Q1; Ptrend < 0.001). Nonlinear analysis identified a threshold at BRI = 2.58: below this point, BRI strongly predicted PDFF reduction (β = -26.048, P < 0.001), whereas the association attenuated above it (β = -1.086, P = 0.024).
CONCLUSIONS: Increased BRI independently correlates with reduced marrow adiposity in postmenopausal women, with a nonlinear threshold effect (BRI = 2.58) suggesting distinct biological mechanisms at lower versus higher adiposity levels. These findings highlight BRI as a potential biomarker for marrow fat dynamics and a target for metabolic bone disease interventions.