[Total body irradiation in the conditioning of autologous bone marrow transplants in acute leukemias and lymphomas].

From january 1984 to may 1986, 31 patients, 15 ANLL, 8 ALL (in remission status) and 8 NHL (6 in remission, 2 in relapse) have been treated with chemo-radiotherapy [cyclophosphamide 60 mg/kg X 2 days + total body irradiation (TBI): 10 Gy/1 fr. in ANLL and NHL patients, 12 Gy/3 fr./3 days with 4 Gy boost testicular dose in ALL] and autologous bone marrow transplantation (BMT). Seventeen patients are alive, 16 in remission: 9 (60%) ANLL, 2 (25%) ALL, 5 (62%) NHL (median 8+ months, follow up 1+/29+); 2 patients presented interstitial pneumonitis (6.45%). In this series, very good results have been achieved in ANLL, where no relapse was noted, encouraging achievements in NHL, with 2/6 relapses; unsatisfactory results in ALL, with 4/8 relapse. Advantages and disadvantages of autologous relative to allogenic BMT, and of conditioning regimen with or without TBI are discussed.