Journal of ethnopharmacology · 2018
Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models.
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De Sales Igor Rafael Praxedes, Formiga Rodrigo De Oliveira, Machado Flávia Danniele Frota, Nascimento Raphaela Francelino, Pessoa Matheus Marley Bezerra, Barros Monique Emanuela Frutuoso Xavier, Vieira Giciane Carvalho, Gadelha Francisco Allysson Assis Ferreira, Marinho Alexsandro Fernandes, Barbosa Filho José Maria, Júnior Raimundo Fernandes De Araújo, Antunes Aurigena Araújo, Batista Leônia Maria
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves and roots of Cissampelos sympodialis (Menispermaceae) are used by indian tribes and in folk medicine to treat genitourinary infections, inflammation, asthma and gastrointestinal disorders.
MATERIAL AND METHODS: The standardized ethanolic extract (Cs-EtOHE) and alkaloids total fraction (Cs-TAF) obtained from aerial parts of C. sympodialis were evaluated in several models of acute gastric ulcers. The antisecretory and/or neutralizing mechanisms of the gastric acid secretion, cytoprotective, antioxidant and immunoregulatory mechanisms were also evaluated.
RESULTS: Cs-EtOHE and Cs-TAF presented a reduction in gastric mucosa lesions against ethanol, NSAIDs, hypothermic restraint-stress and gastric juice containment induced ulcer models. This activity is related to alkaloids present in the extract, and involves the participation of sulfhydryl compounds, nitric oxide, KATP channels, prostaglandins, decreased levels of IL-1β and TNF-α and increased levels of GSH and IL-10.
CONCLUSION: The data indicate gastroprotective activity, due to the participation of the cytoprotective, antioxidant and immunoregulatory mechanisms.
MATERIAL AND METHODS: The standardized ethanolic extract (Cs-EtOHE) and alkaloids total fraction (Cs-TAF) obtained from aerial parts of C. sympodialis were evaluated in several models of acute gastric ulcers. The antisecretory and/or neutralizing mechanisms of the gastric acid secretion, cytoprotective, antioxidant and immunoregulatory mechanisms were also evaluated.
RESULTS: Cs-EtOHE and Cs-TAF presented a reduction in gastric mucosa lesions against ethanol, NSAIDs, hypothermic restraint-stress and gastric juice containment induced ulcer models. This activity is related to alkaloids present in the extract, and involves the participation of sulfhydryl compounds, nitric oxide, KATP channels, prostaglandins, decreased levels of IL-1β and TNF-α and increased levels of GSH and IL-10.
CONCLUSION: The data indicate gastroprotective activity, due to the participation of the cytoprotective, antioxidant and immunoregulatory mechanisms.
Предметные рубрики MeSH
AnimalsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsAntioxidantsCissampelosColonCytokinesDisease Models, AnimalEthanolGastric MucosaGlutathioneKATP ChannelsMaleMiceNitric OxidePhytotherapyPlant Components, AerialPlant ExtractsProstaglandinsRats, WistarRestraint, PhysicalStomach UlcerStress, Physiological