Phytochemistry · 2016
Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols.
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da Rocha Claudia Quintino, de-Faria Felipe Meira, Marcourt Laurence, Ebrahimi Samad Nejad, Kitano Bruna Tiemi, Ghilardi Amanda Franceschini, Luiz Ferreira Anderson, de Almeida Ana Cristina Alves, Dunder Ricardo José, Souza-Brito Alba Regina Monteiro, Hamburger Matthias, Vilegas Wagner, Queiroz Emerson Ferreira, Wolfender Jean-Luc
Аннотация
The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian medicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, glutathione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenylethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy.