[In vitro activities of Odorrana grahami antimicrobial peptides from skin against 5 pathogenic bacteria].

OBJECTIVE

To evaluate the efficiency of 4 Odorrana grahami antimicrobial peptides from skin against 5 pathogenic bacteria, include 2 wild strains and 7 resistant strains.

METHODS

Broth microdilution antimicrobial susceptibility test was used for bacteria that growed aerobically.

RESULTS

The 4 Odorrana grahami antimicrobial peptides were basically in vitro efficient agents for inhibition against to methicillin-resistant coagulase negative Staphylococcus (MRSCN, 85460), wild Staphylococcus aureus (24157), penicillin-resistant Streptococcus pneumoniae (PRSP, 84688 and 91452), class I beta-lactamase Enterobacter cloacae (AmpC, 85439 and 93543), wild Escherichia coli (84492), extended-spectrum beta-lactamases Escherichia coli (ESBL, 84492), inhabitor-resistant TEM beta-lactamase Escherichia coli (IRT, 85580).

CONCLUSION

The 4 Odorrana grahami antimicrobial peptides from skin have broad spectrum antimicrobial activity; especially have in vitro activity to resistant strains. So it is hopeful to be developed as the antimicrobial agent as well as the disinfectant and the antiseptic.