[Allergen immunotherapy with an immunochemically characterized grass pollen extract: change in follow-up sensitization parameters].

A perennial hyposensitization treatment over 2 years was performed in 18 pollen-allergic patients (14 children, 4 adults) with a standardized and purified graspollen extract. The selection for therapy was provided by allergen titration in skin prick test, conjunctival test and by the estimation of specific IgE to timothy. The reported decrease of seasonal symptoms was accompanied by reduced sensitivity in skin test and conjunctival provocation test (p less than 0.001, p less than 0.05). No consistent change in specific IgE was observed at the end of the study. Specific IgG antibodies significantly rised and persisted (p less than 0.001). A successful hyposensitization treatment with graspollen could be monitored by in-vivo and in-vitro parameters.