Management of Gilles de la Tourette syndrome using sulpiride.

One hundred and fourteen patients with Gilles de la Tourette syndrome have been reviewed. Sixty-three were managed using sulpiride, and worthwhile beneficial effects occurred in 59%. Our experience with sulpiride compared to other drug treatments is discussed. The main adverse side effects of sulpiride treatment were sustained drowsiness and, possibly, depression. Tardive dyskinesia was not reported in our cohort.