[Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease].

OBJECTIVE

To explore the roles of granulocyte colony-stimulating factor in the pathogenesis of moyamoya disease.

METHODS

Serum G-CSF concentrations were measured using enzyme linked immunosorbent assay (ELISA) in 20 children with moyamoya disease and 20 healthy children.

RESULTS

Serum G-CSF concentration (35.7+/-10.3 pg/mL) in children with moyamoya disease was significantly higher than that in healthy controls (23.5+/-3.8 pg/mL) (p<0.01).

CONCLUSIONS

The elevated serum G-CSF concentration in children with moyamoya disease suggests that G-CSF may play an important role in the pathogenesis of moyamoya disease.