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DOI 10.1016/j.bbmt.2014.10.021

Медицинская библиотека · Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014

Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.

Arai Sally, Arora Mukta, Wang Tao, Spellman Stephen R, He Wensheng, Couriel Daniel R, Urbano-Ispizua Alvaro, Cutler Corey S, Bacigalupo Andrea A, Battiwalla Minoo, Flowers Mary E, Juckett Mark B, Lee Stephanie J, Loren Alison W, Klumpp Thomas R, Prockup Susan E, Ringdén Olle T H, Savani Bipin N, Socié Gérard, Schultz Kirk R, Spitzer Thomas, Teshima Takanori, Bredeson Christopher N, Jacobsohn David A, Hayashi Robert J, Drobyski William R, Frangoul Haydar A, Akpek Görgün, Ho Vincent T, Lewis Victor A, Gale Robert Peter, Koreth John, Chao Nelson J, Aljurf Mahmoud D, Cooper Brenda W, Laughlin Mary J, Hsu Jack W, Hematti Peiman, Verdonck Leo F, Solh Melhelm M, Norkin Maxim, Reddy Vijay, Martino Rodrigo, Gadalla Shahinaz, Goldberg Jenna D, McCarthy Philip L, Pérez-Simón José A, Khera Nandita, Lewis Ian D, Atsuta Yoshiko, Olsson Richard F, Saber Wael, Waller Edmund K, Blaise Didier, Pidala Joseph A, Martin Paul J, Satwani Prakash, Bornhäuser Martin, Inamoto Yoshihiro, Weisdorf Daniel J, Horowitz Mary M, Pavletic Steven Z, Graft-vs-Host Disease Working Committee of the CIBMTR

СтатьяНаблюдательное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАПеревод пока не подготовлен

Аннотация

Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio = 1.19, P < .0001), and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5 years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.

Для цитирования: Arai Sally, Arora Mukta, Wang Tao, Spellman Stephen R, He Wensheng, Couriel Daniel R, Urbano-Ispizua Alvaro, Cutler Corey S, Bacigalupo Andrea A, Battiwalla Minoo, Flowers Mary E, Juckett Mark B, Lee Stephanie J, Loren Alison W, Klumpp Thomas R, Prockup Susan E, Ringdén Olle T H, Savani Bipin N, Socié Gérard, Schultz Kirk R, Spitzer Thomas, Teshima Takanori, Bredeson Christopher N, Jacobsohn David A, Hayashi Robert J, Drobyski William R, Frangoul Haydar A, Akpek Görgün, Ho Vincent T, Lewis Victor A, Gale Robert Peter, Koreth John, Chao Nelson J, Aljurf Mahmoud D, Cooper Brenda W, Laughlin Mary J, Hsu Jack W, Hematti Peiman, Verdonck Leo F, Solh Melhelm M, Norkin Maxim, Reddy Vijay, Martino Rodrigo, Gadalla Shahinaz, Goldberg Jenna D, McCarthy Philip L, Pérez-Simón José A, Khera Nandita, Lewis Ian D, Atsuta Yoshiko, Olsson Richard F, Saber Wael, Waller Edmund K, Blaise Didier, Pidala Joseph A, Martin Paul J, Satwani Prakash, Bornhäuser Martin, Inamoto Yoshihiro, Weisdorf Daniel J, Horowitz Mary M, Pavletic Steven Z, Graft-vs-Host Disease Working Committee of the CIBMTR. Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2014. DOI: 10.1016/j.bbmt.2014.10.021.

Предметные рубрики MeSH

AdolescentAdultBone Marrow TransplantationChildChild, PreschoolChronic DiseaseFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansInfantInfant, NewbornInternational CooperationLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteMaleMiddle AgedMyeloablative AgonistsMyelodysplastic SyndromesOdds RatioSurvival AnalysisTransplantation, Homologous
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