Journal of applied physiology (Bethesda, Md. : 1985) · 2024
Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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MoTrPAC Study Group, Jakicic John M, Kohrt Wendy M, Houmard Joseph A, Miller Michael E, Radom-Aizik Shlomit, Rasmussen Blake B, Ravussin Eric, Serra Monica, Stowe Cynthia L, Trappe Scott, Abouassi Hiba, Adkins Joshua N, Alekel D Lee, Ashley Euan, Bamman Marcas M, Bergman Bryan C, Bessesen Daniel H, Broskey Nicholas T, Buford Thomas W, Burant Charles F, Chen Haiying, Christle Jeffrey W, Clish Clary B, Coen Paul M, Collier David, Collins Katherine A, Cooper Daniel M, Cortes Tiffany, Cutter Gary R, Dubis Gabriel, Fernández Facundo M, Firnhaber Jonathon, Forman Daniel E, Gaul David A, Gay Nicole, Gerszten Robert E, Goodpaster Bret H, Gritsenko Marina A, Haddad Fadia, Huffman Kim M, Ilkayeva Olga, Jankowski Catherine M, Jin Christopher, Johannsen Neil M, Johnson Johanna, Kelly Leslie, Kershaw Erin, Kraus William E, Laughlin Maren, Lester Bridget, Lindholm Malene E, Lowe Adam, Lu Ching-Ju, McGowan Joan, Melanson Edward L, Montgomery Stephen, Moore Samuel G, Moreau Kerrie L, Muehlbauer Michael, Musi Nicolas, Nair Venugopalan D, Newgard Christopher B, Newman Anne B, Nicklas Barbara, Nindl Bradley C, Ormond Kelly, Piehowski Paul D, Qian Wei-Jun, Rankinen Tuomo, Rejeski W Jack, Robbins Jeremy, Rogers Renee J, Rooney Jessica L, Rushing Scott, Sanford James A, Schauer Irene E, Schwartz Robert S, Sealfon Stuart C, Slentz Cris, Sloan Ruben, Smith Kevin S, Snyder Michael, Spahn Jessica, Sparks Lauren M, Stefanovic-Racic Maja, Tanner Charles J, Thalacker-Mercer Anna, Tracy Russell, Trappe Todd A, Volpi Elena, Walsh Martin J, Wheeler Matthew T, Willis Leslie
Аннотация
Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of these molecular responses to exercise has not been developed. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a multicenter study designed to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. MoTrPAC contains both a preclinical and human component. The details of the human studies component of MoTrPAC that include the design and methods are presented here. The human studies contain both an adult and pediatric component. In the adult component, sedentary participants are randomized to 12 wk of Control, Endurance Exercise Training, or Resistance Exercise Training with outcomes measures completed before and following the 12 wk. The adult component also includes recruitment of highly active endurance-trained or resistance-trained participants who only complete measures once. A similar design is used for the pediatric component; however, only endurance exercise is examined. Phenotyping measures include weight, body composition, vital signs, cardiorespiratory fitness, muscular strength, physical activity and diet, and other questionnaires. Participants also complete an acute rest period (adults only) or exercise session (adults, pediatrics) with collection of biospecimens (blood only for pediatrics) to allow for examination of the molecular responses. The design and methods of MoTrPAC may inform other studies. Moreover, MoTrPAC will provide a repository of data that can be used broadly across the scientific community.NEW & NOTEWORTHY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will be the first large trial to isolate the effects of structured exercise training on the molecular mechanisms underlying the health benefits of exercise and physical activity. By generating a compendium of the molecular responses to exercise, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. Presented here is the design, protocols, and procedures for the MoTrPAC human studies.