Медицинская библиотека · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2009

[Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in children].

Chen Jin-ping, Li Hai-pian, Jin Sheng-hua, Zhang Jin-tao, Li Jun

Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To detect the serum levels of melanocyte antibodies and explore the relation between melanoma antigen recognized by T-cells (MART-1) and vitiligo in children.

METHODS

The serum samples were collected from children with vitiligo to test the autoantibodies, and divided into low- and high-titer group according to the test results. Melanocytes were incubated with the serum samples, and the changes of melanocyte surface antigen were evaluated using specific MART-1 antibody.

RESULTS

The serum melanocyte antibody levels in children with vitiligo were significantly higher than those in normal subjects. The expression level of melanocyte surface antigen MART-1 increased obviously after incubation of the melanocyte with high antibody titer serum samples, and MART-1 was found to specifically bind to specific MART-1 antibody.

CONCLUSION

Melanocytes MART-1 may correlate to the autoimmune mechanism in children with vitiligo.

Для цитирования: Chen Jin-ping, Li Hai-pian, Jin Sheng-hua, Zhang Jin-tao, Li Jun. [Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in children].. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2009.

Предметные рубрики MeSH

Adolescent Autoantibodies Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female Humans MART-1 Antigen Male Melanocytes T-Lymphocytes Vitiligo

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