Epilepsia · 2026
Interictal epileptiform discharges are involved in momentary lapses of attention in children with epilepsy.
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Thieux Marine, Bouet Romain, Jung Julien, Kahane Philippe, Vercueil Laurent, Martinet Lucie, Perrone-Bertolotti Marcela, Lachaux Jean-Philippe, de Bellescize Julitta, Herbillon Vania
Аннотация
OBJECTIVE: Attention impairments are common in children with epilepsy and widely impact their quality of life. Interictal epileptiform discharges (IEDs) may induce subtle dysfunctions of various cognitive processes, but data regarding the impact of IEDs on sustained attention remain limited. The objective of the present study was to evaluate the impact of IEDs on continuous undivided attention in children with epilepsy, controlling for the number of treatments, type of epilepsy, frequency of seizures in the past year, age at onset, and comorbid attention disorder.
METHODS: Using a computerized sustained attention test synchronized with the electroencephalogram in 61 children with diverse epilepsy syndromes, reaction time (RT), errors, attention stability over time, and the event-related potential (ERP) in Pz (related to attentional engagement) were collected. The cumulative impact of IEDs was evaluated using multivariate models controlling for epilepsy-related factors. The transient impact of IEDs was assessed by comparing responses in trials with and without IEDs.
RESULTS: IEDs were associated with attention fluctuations independently from other epilepsy-related factors. In terms of cumulative impact, a higher IED rate was associated with a poorer sustained attention performance over the entire task. In terms of transient impact, trials disrupted by IEDs were characterized by longer RT and a lower amplitude of the ERP extending over a long time window that included attentional processing (P300).
SIGNIFICANCE: These results suggest that IEDs may negatively impact sustained attention, independently of other epilepsy-related features. These findings support the hypothesis that IEDs could contribute to subtle attentional deficits and serve as potential biomarkers of abnormal brain function.
METHODS: Using a computerized sustained attention test synchronized with the electroencephalogram in 61 children with diverse epilepsy syndromes, reaction time (RT), errors, attention stability over time, and the event-related potential (ERP) in Pz (related to attentional engagement) were collected. The cumulative impact of IEDs was evaluated using multivariate models controlling for epilepsy-related factors. The transient impact of IEDs was assessed by comparing responses in trials with and without IEDs.
RESULTS: IEDs were associated with attention fluctuations independently from other epilepsy-related factors. In terms of cumulative impact, a higher IED rate was associated with a poorer sustained attention performance over the entire task. In terms of transient impact, trials disrupted by IEDs were characterized by longer RT and a lower amplitude of the ERP extending over a long time window that included attentional processing (P300).
SIGNIFICANCE: These results suggest that IEDs may negatively impact sustained attention, independently of other epilepsy-related features. These findings support the hypothesis that IEDs could contribute to subtle attentional deficits and serve as potential biomarkers of abnormal brain function.