Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2006
Bilateral impairment of intracortical inhibition in delayed-onset posthemiplegic dystonia: pathophysiological implications.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Trompetto Carlo, Buccolieri Alessandro, Bove Marco, Brichetto Gianpaolo, Avanzino Laura, Marinelli Lucio, Abbruzzese Giovanni
Аннотация
OBJECTIVE: To study short interval intracortical inhibition (SICI) in a rare patient with segmental dystonia of the left upper limb due to a vascular lesion in the contralateral putamen without corticospinal tract involvement.
METHODS: Paired-pulse transcranial magnetic stimulation (TMS) was applied to both hemispheres in a conditioning-test paradigm. Six interstimulus intervals (ISIs) and 4 conditioning stimulation intensities were investigated in two separate sessions.
RESULTS: Motor evoked potentials upon single-pulse TMS were within the normal range, whereas paired-pulse TMS revealed major changes in cortical excitability, proving that SICI was bilaterally absent.
CONCLUSIONS: The bilateral impairment of SICI cannot be considered the cause of dystonic contractions, but just a predisposing factor.
SIGNIFICANCE: The absence of SICI might be regarded as a condition able to promote maladaptive plastic changes triggered by focal lesions in the putamen.
METHODS: Paired-pulse transcranial magnetic stimulation (TMS) was applied to both hemispheres in a conditioning-test paradigm. Six interstimulus intervals (ISIs) and 4 conditioning stimulation intensities were investigated in two separate sessions.
RESULTS: Motor evoked potentials upon single-pulse TMS were within the normal range, whereas paired-pulse TMS revealed major changes in cortical excitability, proving that SICI was bilaterally absent.
CONCLUSIONS: The bilateral impairment of SICI cannot be considered the cause of dystonic contractions, but just a predisposing factor.
SIGNIFICANCE: The absence of SICI might be regarded as a condition able to promote maladaptive plastic changes triggered by focal lesions in the putamen.