Obesity surgery · 2025
Association of High-Sensitivity C-Reactive Protein Levels with Proximal Airway CT Morphology in Obesity.
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Yu Xin, Cheng Zhong-Yuan, Feng You-Zhen, Li Ying-Long, Jiang Shu-Wen, Wang Cun-Chuan, Cai Xiang-Ran
Аннотация
OBJECTIVE: Obesity and airway collapse are closely associated, yet the underlying mechanisms remain unclear. This study aimed to evaluate airway collapsibility in relation to markers of adiposity and high-sensitivity C-reactive protein (hs-CRP) levels in obese individuals.
METHODS: We conducted a cross-sectional study comparing changes in the lumen area and circularity of proximal airways using chest CT imaging in four groups: obese individuals (BMI 30-39.9 kg/m2) with low hs-CRP (< 3 mg/L), obese individuals with moderate hs-CRP (3-8 mg/L), morbidly obese individuals (BMI ≥ 40 kg/m2) with moderate hs-CRP, and morbidly obese individuals with high hs-CRP (> 8 mg/L).
RESULTS: Morbidly obese individuals with high hs-CRP exhibited the most pronounced airway collapse, with regional asymmetry in collapsibility. hs-CRP was significantly associated with BMI, android and gynoid fat mass, and subcutaneous adipose tissue area (all P < 0.001). In multivariate analysis, change in airway circularity was associated with BMI and change in airway lumen area was associated with BMI and hs-CRP, but neither was related to adiposity distribution.
CONCLUSION: The inflammatory aspects of obesity, reflected by hs-CRP, may exacerbate proximal airway collapse and regional ventilation abnormalities beyond the mechanical effects of fat accumulation.
METHODS: We conducted a cross-sectional study comparing changes in the lumen area and circularity of proximal airways using chest CT imaging in four groups: obese individuals (BMI 30-39.9 kg/m2) with low hs-CRP (< 3 mg/L), obese individuals with moderate hs-CRP (3-8 mg/L), morbidly obese individuals (BMI ≥ 40 kg/m2) with moderate hs-CRP, and morbidly obese individuals with high hs-CRP (> 8 mg/L).
RESULTS: Morbidly obese individuals with high hs-CRP exhibited the most pronounced airway collapse, with regional asymmetry in collapsibility. hs-CRP was significantly associated with BMI, android and gynoid fat mass, and subcutaneous adipose tissue area (all P < 0.001). In multivariate analysis, change in airway circularity was associated with BMI and change in airway lumen area was associated with BMI and hs-CRP, but neither was related to adiposity distribution.
CONCLUSION: The inflammatory aspects of obesity, reflected by hs-CRP, may exacerbate proximal airway collapse and regional ventilation abnormalities beyond the mechanical effects of fat accumulation.