Open veterinary journal · 2025
Therapeutic efficacy of liposomal caffeic acid in high-fat diet-induced obesity in rats: Targeting hedgehog signalling pathway, adipokines, and insulin resistance.
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Alansari Wafa S, El-Emam Mahran Mohamed Abd, Altalhi Rawan, Khater Safaa I, Khamis Tarek, Sherkawy Hoda S, Fares Abdelhamid M, Lotfy Marwa M, Youssef Ola Mohammed, Yassin Engy Mohamed Mohamed
Аннотация
BACKGROUND: Obesity spurred by a high-fat diet (HFD) has emerged as a significant worldwide health issue. Caffeic acid (CA) is a plant-derived phenolic compound found in various foods such as coffee, wine, and tea. It exhibits antioxidant, anti-inflammatory, and anticarcinogenic properties. However, the therapeutic potential of this substance is hindered by its poor water solubility and low oral bioavailability.
AIM: In this study, CA was loaded into liposomes Caffeic Acid -Loaded Liposomes (CA-Lip) , and the potential role of CA-Lip in mitigating HFD-induced obesity in rats was examined.
METHODS: Forty male Wistar rats were used in this investigation. They were allocated into four groups: the first was fed a regular diet; the second received a normal diet plus CA-Lip; the third received an HFD; and the fourth received both an HFD and CA-Lip.
RESULTS: The developed CA-Lip showed a particle size of 125 nm, zeta potential of -15 mV, and entrapment efficiency of 82%. The HFD+CA-Lip group's body weight was considerably lower than that of the HFD group. The HFD+CA-Lip group also showed a significant improvement in their serum lipid profiles. CA-Lip lowered levels of adipokines, which encourage inflammation, including leptin, interleukin-6, and tumor necrosis factor-α. It also reduced the size of the adipocytes when compared to the HFD control group. Furthermore, it reversed the HFD-induced upregulation of Hh genes [protein patched homolog 1 (PTCH1), Hh-interacting protein (HHIP), glioma-associated oncogene homolog 1 (Gli1), and smoothened (Smo) receptor] in adipose tissue.
CONCLUSION: In summary, CA-Lip may reduce obesity and related inflammation by activating the Hh signaling pathway.
AIM: In this study, CA was loaded into liposomes Caffeic Acid -Loaded Liposomes (CA-Lip) , and the potential role of CA-Lip in mitigating HFD-induced obesity in rats was examined.
METHODS: Forty male Wistar rats were used in this investigation. They were allocated into four groups: the first was fed a regular diet; the second received a normal diet plus CA-Lip; the third received an HFD; and the fourth received both an HFD and CA-Lip.
RESULTS: The developed CA-Lip showed a particle size of 125 nm, zeta potential of -15 mV, and entrapment efficiency of 82%. The HFD+CA-Lip group's body weight was considerably lower than that of the HFD group. The HFD+CA-Lip group also showed a significant improvement in their serum lipid profiles. CA-Lip lowered levels of adipokines, which encourage inflammation, including leptin, interleukin-6, and tumor necrosis factor-α. It also reduced the size of the adipocytes when compared to the HFD control group. Furthermore, it reversed the HFD-induced upregulation of Hh genes [protein patched homolog 1 (PTCH1), Hh-interacting protein (HHIP), glioma-associated oncogene homolog 1 (Gli1), and smoothened (Smo) receptor] in adipose tissue.
CONCLUSION: In summary, CA-Lip may reduce obesity and related inflammation by activating the Hh signaling pathway.