Opioid-serotoninergic dysregulation in the pathophysiology of Tourette's syndrome.

In the following communication the major neurotransmitter systems postulated to be involved in the pathophysiology of Tourette's syndrome are discussed. Malfunctions of the opioid and serotoninergic systems are discussed regarding their role in the pathophysiology of the neuropsychological, behavioural and other manifestations of the disease.