Morphometry of Mast Cells in the Tongue Tissues of the White Rats under Stress Conditions.

We studied the effect of repeated immobilization stress against the background of preliminary intranasal administration of valine-containing glyproline Pro-Gly-Pro-Val (100 μg/kg) on the morphometric parameters of mast cells (mastocytes) in the connective tissue of the mucosal and muscular layers of the tongue in male Wistar rats. Repeated stress increased in the density of distribution, mean size, and degranulation index of mast cells in both layers. Preliminary administration of the peptide decreased the mean area and degranulation index of mast cells, which suggests that the peptide has a stabilizing effect on the morphological structure and activity of mast cells.