[Vitamin A and E allowance of the body in xenobiotic exposure].

The results are presented of the clinico-experimental studies conducted in patients with diseases of the respiratory organs. Providing with tocopherol, lipid metabolism and peroxidation parameters were studied in these patients in the time course of combined drug therapy. Different variants of providing with vitamins A and E were simulated in rats. It was shown that both under clinical and experimental conditions, administration of xenobiotics produced the devitaminizing effect which was manifest in tocopherol and retinol deficiency, activation of lipid peroxidation in the blood, bronchoalveolar lavage, in the lungs and liver. The authors have recommended the control over providing with vitamins A and E during the drug therapy of such patients, as well as differential approach to the corrective dietotherapy with the rations enriched with vitamins A and E; the vitamins are especially necessary for the patients with chronic broncho-pulmonary diseases in the presence of obesity and lipid metabolism disorders.