[A comparative study of anapriline and carvedilol effectiveness in patients with thyrotoxicosis in pre- and postoperative periods].

Thyrotoxicosis often affects cardiovascular system. Structural-functional condition of the myocardium is essential in the outcome of surgical intervention on the thyroid in thyrotoxicosis and indicates effectiveness of the treatment. A comparative trial studied the effects of beta-blockers (anaprilin and carvedilol) on preoperative condition of left-ventricular (LV) myocardium and late after subtotal resection of the thyroid gland. 27 thyrotoxicosis patients with myocardial remodeling in the form of concentric LV hypertrophy entered the trial. Though in preoperative preparation anapriline is recommended, in postoperative period it is better to use carvedilol as it has a good effect on reverse development of myocardial remodeling and hemodynamics in view of its balanced beta- and alpha-adrenoblocking action.