Journal of neurology, neurosurgery, and psychiatry · 2013
Association of silent lacunar infarct with brain atrophy and cognitive impairment.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Thong Jamie Yu Jin, Hilal Saima, Wang Yanbo, Soon Hock Wei, Dong Yanhong, Collinson Simon Lowes, Anh Tuan Ta, Ikram Mohammad Kamran, Wong Tien Yin, Venketasubramanian Narayanaswamy, Chen Christopher, Qiu Anqi
Аннотация
OBJECTIVE: Silent lacunar infarct (SLI) is associated with cognitive decline and linked to an increased risk of stroke and dementia. We examined the association of SLI with MRI measures of cortical thickness, subcortical and lateral ventricular shapes and cognition in 285 ethnic Chinese elderly.
METHODS: SLI, cortical thickness, shapes of subcortical and ventricular structures were quantified using MRI. The cognitive performance was assessed using comprehensive neuropsychological tests. Linear regression was used to examine associations among SLI, brain measures and cognition.
RESULTS: SLI was associated with atrophy in multiple subcortical structures, ventricular enlargement and widespread cortical thinning. Both SLI and atrophy were independently related to poorer performance in attention, memory and language domains. Only SLI was associated with visuomotor speed and executive function, while atrophy mediated the association between SLI and visuoconstruction.
CONCLUSIONS: Our findings support a vascular contribution to neurodegeneration and cognitive impairment.
METHODS: SLI, cortical thickness, shapes of subcortical and ventricular structures were quantified using MRI. The cognitive performance was assessed using comprehensive neuropsychological tests. Linear regression was used to examine associations among SLI, brain measures and cognition.
RESULTS: SLI was associated with atrophy in multiple subcortical structures, ventricular enlargement and widespread cortical thinning. Both SLI and atrophy were independently related to poorer performance in attention, memory and language domains. Only SLI was associated with visuomotor speed and executive function, while atrophy mediated the association between SLI and visuoconstruction.
CONCLUSIONS: Our findings support a vascular contribution to neurodegeneration and cognitive impairment.
Предметные рубрики MeSH
AgedAged, 80 and overAtrophyBasal GangliaBrainBrain StemCerebral CortexCognitive DysfunctionDementia, Multi-InfarctDominance, CerebralFemaleHumansImage Processing, Computer-AssistedImaging, Three-DimensionalInternal CapsuleLateral VentriclesMagnetic Resonance ImagingMaleMental Status ScheduleNeuropsychological TestsSingaporeStroke, Lacunar