[The status of the blood antioxidant system in a chronic typhoid bacterial carrier state].

The problems dealt with in this work, the study of the pathogenesis of chronic Salmonella typhi carriership and the development of preparations for its sanation, are highly topical. The data on the evaluation of the state of antioxidative system in 33 chronic S. typhi carriers are presented. In all carriers a decrease in the activity of this system has been established, mainly in its nonenzymatic part, represented by low-molecular thiols, and an essential decrease in the buffer capacity of the thiosulfide link and catalase activity of the blood has been noted. The use of antioxidants in combination with ampicillin makes it possible to normalize the state of the antioxidative system. In all carriers no S. typhi were isolated during the first month after proposed treatment.