[Clinical study of Chinese ofloxacin].

The effect of Chinese ofloxacin for various infections was compared clinically with that of Japanese ofloxacin. 217 bacteriologically proved cases of infection included 61 of pulmonary infection, 68 urinary infection, 32 typhoid fever, 30 acute gonorrhea, and 26 burn or wound complicated by infection. In 235 pathogenic strains isolated, 185 (78.7%) were Gram-negative bacilli and 50 (21.3%) Gram-positive cocci. 152 patients were given Chinese ofloxacin with an effective rate of 95% and the bacteria clearance rate of 91%. Side-effects such as mild gastrointestinal symptoms and central nerve irritations were seen in the course of treatment; their morbidity was 12.5% and 3.3% respectively. In vitro antibacterial activities of Chinese ofloxacin were determined and showed that most pathogenic strains were susceptible to the drug and correlated with clinical efficacy. Studies revealed that the effectivity, bacteria clearance, and side-effects were similar in using Chinese and Japanese ofloxacin to treat pulmonary and urinary tract infections. The serum and urine concentrations and other principal pharmacokinetics parameters of the two drugs were also identical.