Медицинская библиотека · Molecular psychiatry · 2025

Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.

Liu Siwei, Agartz Ingrid, Allen Paul, Amminger G Paul, Andreassen Ole A, Bachman Peter, Baeza Inmaculada, Baldwin Helen, Bartholomeusz Cali F, Borgwardt Stefan, Catalano Sabrina, Chen Xiaogang, Cho Kang Ik K, Choi Sunah, Colibazzi Tiziano, Cooper Rebecca E, Corcoran Cheryl M, Cropley Vanessa L, de Haan Lieuwe, de la Fuente-Sandoval Camilo, Dolz Montserrat, Ebdrup Bjørn H, Fortea Adriana, Fusar-Poli Paolo, Glenthøj Louise Birkedal, Glenthøj Birte Yding, Haas Shalaila S, Hamilton Holly K, Haut Kristen M, Hayes Rebecca A, He Ying, Heekeren Karsten, Hegelstad Wenche Ten Velden, Hooker Christine I, Horton Leslie E, Hubl Daniela, Hwang Wu Jeong, Kaess Michael, Kasai Kiyoto, Katagiri Naoyuki, Kim Minah, Kindler Jochen, Klaunig Mallory J, Koike Shinsuke, Kristensen Tina D, Kwak Yoo Bin, Kwon Jun Soo, Lawrie Stephen M, Lebedeva Irina, Lemmers-Jansen Imke Lj, León-Ortiz Pablo, Lin Ashleigh, Loewy Rachel L, Ma Xiaoqian, Mathalon Daniel H, McGorry Patrick, McGuire Philip, Michel Chantal, Mizrahi Romina, Mizuno Masafumi, Møller Paul, Mora-Durán Ricardo, Muñoz-Samons Daniel, Nelson Barnaby, Nemoto Takahiro, Nordentoft Merete, Nordholm Dorte, Omelchenko Maria A, Ouyang Lijun, Pantelis Christos, Pariente Jose C, Raghava Jayachandra M, Rasser Paul E, Resch Franz, Reyes-Madrigal Francisco, Rivera-Chávez Luis F, Røssberg Jan I, Rössler Wulf, Salisbury Dean F, Sasabayashi Daiki, Schall Ulrich, Schiffman Jason, Schmidt Andre, Smigielski Lukasz, Sørensen Mikkel E, Sugranyes Gisela, Suzuki Michio, Takahashi Tsutomu, Tamnes Christian K, Tang Jinsong, Theodoridou Anastasia, Thomopoulos Sophia I, Tomyshev Alexander S, Tor Jordina, Uhlhaas Peter J, Værnes Tor G, van Amelsvoort Therese Amj, Velakoulis Dennis, Via Esther, Vinogradov Sophia, Waltz James A, Wenneberg Christina, Westlye Lars T, Wood Stephen J, Yamasue Hidenori, Yuan Liu, Yung Alison R, Chee Michael Wl, Thompson Paul M, Hernaus Dennis, Jalbrzikowski Maria, Lee Jimmy, Zhou Juan H, ENIGMA Clinical High Risk for Psychosis Working Group

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Аннотация

Brain network architecture is anticipated to influence future grey matter loss in individuals at Clinical High Risk (CHR) for psychosis. However, existing studies on grey matter structural network properties in CHR are scarce and constrained by small sample sizes. Here, we examined network topology differences comparing a) CHR versus healthy controls (HC); b) CHR who transitioned to psychosis (CHR-T) versus those who did not (CHR-NT); and c) different subsyndromes. We included structural scans from 1842 CHR individuals and 1417 HC individuals from 31 sites within the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. At the global level, CHR individuals exhibited lower structural covariance (q < 0.001; Cohen's d = 0.164) and less optimal structural network configuration than HC (lower global efficiency and clustering coefficient, d = 0.100,0.087, qs <= 0.027). Though no global difference between CHR-T and CHR-NT, network distinctiveness of the frontal and temporal surface area networks was higher in CHR-T than CHR-NT (d = 0.223,0.237) and HC (d = 0.208,0.219) (qs < 0.001). Network distinctiveness of the frontal cortical thickness network was lower in CHR-T (d = 0.218, q < 0.001) than CHR-NT and HC (d = 0.165, q < 0.001). Importantly, higher network distinctiveness was associated with worse positive symptoms in CHR-NT (frontal surface area, q = 0.008, R2 = 0.013) and at trend with worse negative symptoms in CHR-T (frontal thickness, q = 0.063, R2 = 0.049). Further, the brief intermittent psychotic syndrome subgroup showed more severe network alterations. Together, brain structural networks inform symptoms and the risk of transition to psychosis in CHR individuals.

Для цитирования: Liu Siwei, Agartz Ingrid, Allen Paul, Amminger G Paul, Andreassen Ole A, Bachman Peter, Baeza Inmaculada, Baldwin Helen, Bartholomeusz Cali F, Borgwardt Stefan, Catalano Sabrina, Chen Xiaogang, Cho Kang Ik K, Choi Sunah, Colibazzi Tiziano, Cooper Rebecca E, Corcoran Cheryl M, Cropley Vanessa L, de Haan Lieuwe, de la Fuente-Sandoval Camilo, Dolz Montserrat, Ebdrup Bjørn H, Fortea Adriana, Fusar-Poli Paolo, Glenthøj Louise Birkedal, Glenthøj Birte Yding, Haas Shalaila S, Hamilton Holly K, Haut Kristen M, Hayes Rebecca A, He Ying, Heekeren Karsten, Hegelstad Wenche Ten Velden, Hooker Christine I, Horton Leslie E, Hubl Daniela, Hwang Wu Jeong, Kaess Michael, Kasai Kiyoto, Katagiri Naoyuki, Kim Minah, Kindler Jochen, Klaunig Mallory J, Koike Shinsuke, Kristensen Tina D, Kwak Yoo Bin, Kwon Jun Soo, Lawrie Stephen M, Lebedeva Irina, Lemmers-Jansen Imke Lj, León-Ortiz Pablo, Lin Ashleigh, Loewy Rachel L, Ma Xiaoqian, Mathalon Daniel H, McGorry Patrick, McGuire Philip, Michel Chantal, Mizrahi Romina, Mizuno Masafumi, Møller Paul, Mora-Durán Ricardo, Muñoz-Samons Daniel, Nelson Barnaby, Nemoto Takahiro, Nordentoft Merete, Nordholm Dorte, Omelchenko Maria A, Ouyang Lijun, Pantelis Christos, Pariente Jose C, Raghava Jayachandra M, Rasser Paul E, Resch Franz, Reyes-Madrigal Francisco, Rivera-Chávez Luis F, Røssberg Jan I, Rössler Wulf, Salisbury Dean F, Sasabayashi Daiki, Schall Ulrich, Schiffman Jason, Schmidt Andre, Smigielski Lukasz, Sørensen Mikkel E, Sugranyes Gisela, Suzuki Michio, Takahashi Tsutomu, Tamnes Christian K, Tang Jinsong, Theodoridou Anastasia, Thomopoulos Sophia I, Tomyshev Alexander S, Tor Jordina, Uhlhaas Peter J, Værnes Tor G, van Amelsvoort Therese Amj, Velakoulis Dennis, Via Esther, Vinogradov Sophia, Waltz James A, Wenneberg Christina, Westlye Lars T, Wood Stephen J, Yamasue Hidenori, Yuan Liu, Yung Alison R, Chee Michael Wl, Thompson Paul M, Hernaus Dennis, Jalbrzikowski Maria, Lee Jimmy, Zhou Juan H, ENIGMA Clinical High Risk for Psychosis Working Group. Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.. Molecular psychiatry. 2025. DOI: 10.1038/s41380-025-03304-6.

Предметные рубрики MeSH

Humans Psychotic Disorders Male Female Adult Magnetic Resonance Imaging Brain Gray Matter Young Adult Neuroimaging Adolescent Nerve Net Neural Pathways

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