Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2002
Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Hirota Makoto, Ito Takaaki, Okudela Koji, Kawabe Ryoichi, Yazawa Takuya, Hayashi Hiroyuki, Nakatani Yukio, Fujita Kiyohide, Kitamura Hitoshi
Аннотация
BACKGROUND: In oral lichen planus (OLP), destruction of the basal cell layer, which is one of the characteristic histological features, is seen and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium.
METHODS: We studied mucosal tissues from 19 patients of OLP and 10 controls, with immunohistochemistry for Ki-67, p53, cyclin dependent kinase inhibitors (CDKI) and cyclins. Mitotic count was calculated. TUNEL assay was also performed for evaluation of apoptotic cell death.
RESULTS: Mitotic count, Ki-67 and cyclin D1 labeling indices in the basal and parabasal layers of OLP mucosa were elevated in comparison with those of controls. p53, p21Cip1 and TUNEL indices of OLP mucosa were also increased.
CONCLUSIONS: These complex changes, which concomitantly occur in the injured mucosal epithelium, could contribute to the development and maintenance of characteristic mucosal epithelial architectures seen in OLP.
METHODS: We studied mucosal tissues from 19 patients of OLP and 10 controls, with immunohistochemistry for Ki-67, p53, cyclin dependent kinase inhibitors (CDKI) and cyclins. Mitotic count was calculated. TUNEL assay was also performed for evaluation of apoptotic cell death.
RESULTS: Mitotic count, Ki-67 and cyclin D1 labeling indices in the basal and parabasal layers of OLP mucosa were elevated in comparison with those of controls. p53, p21Cip1 and TUNEL indices of OLP mucosa were also increased.
CONCLUSIONS: These complex changes, which concomitantly occur in the injured mucosal epithelium, could contribute to the development and maintenance of characteristic mucosal epithelial architectures seen in OLP.
Предметные рубрики MeSH
AdultAgedApoptosisBlotting, WesternCell Cycle ProteinsCell DeathCell DivisionCell SurvivalCyclin D1Cyclin ECyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesCyclinsEnzyme InhibitorsEpitheliumFemaleGene Expression RegulationHumansImmunohistochemistryIn Situ Nick-End LabelingKi-67 AntigenLichen Planus, OralMaleMiddle AgedMitosisMouth MucosaStatistics, NonparametricTumor Suppressor Protein p53Tumor Suppressor Proteins