Role of Entorhinal and Parahippocampal in Diagnosis of Alzheimer's Disease from Resting State EEG.

Alzheimer's disease (AD) poses a significant public health problem. An early diagnosis during the initial development stage of this neurodegenerative brain disorder is a requisite. Initial symptoms of AD involve dysfunctioning in brain memory which later progresses toward language, comprehension, reasoning, and social behavior. The degree of dysfunctionality in AD is accompanied by neuronal damage thereby leading to alteration in functional connectivity of brain regions with AD progression. In literature, substantial studies have focused on topological brain function characteristics, scalp EEG temporal features, and functional MRI or PET scan to diagnose AD. However, source domain based study using EEG is limited. This work establishes the significance of EEG based source domain connectivity in AD diagnosis. In particular, the cortical sources, Parahippocampal and Entorhinal, are particularly studied for cognitive processes and memory in AD and healthy control (HC). A publicly available AD and HC resting state EGG dataset is utilized for this purpose. The dipole imaging method converts surface EEG information into source space. Functional connectivity (FC), supervised classification, frequency analysis, and clustering are then utilized to establish the importance of the entorhinal and parahippocampal in AD diagnosis. The entorhinal source involved in memory is found to be a potential biomarker for AD diagnosis. This memory-associated source dynamics-based approach can further lead to early diagnosis of AD.