Quinolone derivatives and their antifungal activities: An overview.

More than 300 million people suffer from the incidence of life-threatening invasive fungal infections, resulting in over 1.35 million deaths annually. Currently, the antifungal agents available in clinics are rather limited, and the rapid development of resistance to the existing antifungal drugs has further aggravated mortality. Quinolones possess a broad spectrum of chemotherapeutic properties and demonstrate considerable antifungal activities as well. Various quinolone derivatives have been screened for their antifungal activities, and some of them exhibit excellent potency against both drug-susceptible and drug-resistant fungi. This review aims to outline the recent advances in quinolone derivatives as potential antifungal agents and summarize the structure-activity relationship, to provide insights for the rational design of more active candidates.