The novel nano-electrospray delivery of curcumin via ultrasound assisted Balangu (Lallemantia royleana) hydrocolloid-chickpea protein interaction.

This research examines the development of complexes between chickpea protein isolate and Balangu seed gum using ultrasound (200 W, 350 W, 500 W, 650 W, and 800 W) to curcumin delivery by electrospray. Higher ultrasound powers (650 W and 800 W) enhanced the formation of complexes, as confirmed by FTIR and XRD. Complexes treated at 650 W demonstrated optimal solution properties for electrospraying, featuring the lowest surface tension of 31.79 mN/m and the highest zeta potential an electrical conductivity of -68.46 mV, and 1896 μS/cm, respectively. The electrospray effectively produced nanoparticles from the 650 W-treated complex solution, achieving a high curcumin encapsulation efficiency (93.67 ± 1.22 %). Loading curcumin into the complex solution altered the nanoparticles' morphology, resulting in more uniform particles. In the small intestine simulation, the hydrolysis of complex particles led to a significant curcumin release of 100 % within 480 min. The best-fitting model for curcumin release from complexes was the Peppas-Sahlin.