Unmasking the prevalence of amyloid cardiomyopathy in the real world: results from Phase 2 of the AC-TIVE study, an Italian nationwide survey.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Merlo Marco, Pagura Linda, Porcari Aldostefano, Cameli Matteo, Vergaro Giuseppe, Musumeci Beatrice, Biagini Elena, Canepa Marco, Crotti Lia, Imazio Massimo, Forleo Cinzia, Cappelli Francesco, Perfetto Federico, Favale Stefano, Di Bella Gianluca, Dore Franca, Girardi Francesca, Tomasoni Daniela, Pavasini Rita, Rella Valeria, Palmiero Giuseppe, Caiazza Martina, Carella Maria Cristina, Igoren Guaricci Andrea, Branzi Giovanna, Caponetti Angelo Giuseppe, Saturi Giulia, La Malfa Giovanni, Merlo Andrea Carlo, Andreis Alessandro, Bruno Francesco, Longo Francesca, Rossi Maddalena, Varrà Guerino Giuseppe, Saro Riccardo, Di Ienno Luca, De Carli Giuseppe, Giacomin Elisa, Arzilli Chiara, Limongelli Giuseppe, Autore Camillo, Olivotto Iacopo, Badano Luigi, Parati Gianfranco, Perlini Stefano, Metra Marco, Emdin Michele, Rapezzi Claudio, Sinagra Gianfranco
Аннотация
METHODS AND RESULTS: This is an Italian prospective multicentre study, involving a clinical and instrumental work-up to assess AC prevalence among patients ≥55 years old with an echocardiogram suggestive of AC (i.e. at least one echocardiographic red flag of AC in hypertrophic, non-dilated left ventricles with preserved ejection fraction). The study was registered at ClinicalTrials.gov (NCT04738266). Overall, 381 patients with an echocardiogram suggestive of AC were identified among a cohort of 5315 screened subjects, and 217 patients completed the investigations. A final diagnosis of AC was made in 62 patients with an estimated prevalence of 29% (95% confidence interval 23%-35%). Transthyretin-related AC (ATTR-AC) was diagnosed in 51 and light chain-related AC (AL-AC) in 11 patients. Either apical sparing or a combination of ≥2 other echocardiographic red flags, excluding interatrial septum thickness, provided a diagnostic accuracy >70%.
CONCLUSION: In a cohort of consecutive adults with echocardiographic findings suggestive of AC and preserved left ventricular ejection fraction, the prevalence of AC (either ATTR or AL) was 29%. Easily available echocardiographic red flags, when combined together, demonstrated good diagnostic accuracy.