First reported case of sextuplets conceived via letrozole for ovulation induction.

OBJECTIVE

To report the first case of sextuplets conceived via letrozole during ovulation induction.

DESIGN

Case report.

SETTING

Private fertility clinic.

PATIENT(S): A 32-year-old female with a history of secondary infertility and polycystic ovary syndrome.

INTERVENTION(S): Letrozole, 7.5 mg, on cycle days 3-7 after a progesterone-induced menses.

MAIN OUTCOME MEASURE(S): Clinical pregnancy.

RESULT(S): Sexchorionic-sexamniotic pregnancy.

CONCLUSION(S): High-order multiple gestations are possible with letrozole ovulation induction, so patients should be counseled appropriately and follicle monitoring considered.