Apathy, depression, and dementia risk in older adults: A global collaborative study.
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Oh Dae Jong, Lipnicki Darren M, Harrison Fleur, Han Ji Won, Kim Tae Hui, Kwak Kyung Phil, Kim Bong Jo, Kim Shin Gyeom, Kim Jeong Lan, Moon Seok Woo, Park Joon Hyuk, Ryu Seung-Ho, Youn Jong Chul, Lee Dong Young, Lee Dong Woo, Lee Seok Bum, Lee Jung Jae, Jhoo Jin Hyeong, Castro-Costa Erico, Davis Daniel, Lipton Richard B, Katz Mindy J, Preux Pierre-Marie, Guerchet Maëlenn, Scarmeas Nikolaos, Yannakoulia Mary, Kosmidis Mary, Rolandi Elena, Davin Annalisa, Rossi Michele, Gureje Oye, Ojagbemi Akin, Elugbadebo Olufisayo, Riedel-Heller Steffi, Roehr Susanne, Pabst Alexander, Brodaty Henry, Sachdev Perminder S, Kim Ki Woong
Аннотация
METHODS: We analyzed data from 12,646 older adults without baseline dementia across ten population-based cohorts from six continents (Cohort Studies of Memory in an International Consortium study). Apathy, depression, and dementia outcomes were assessed using harmonization protocols.
RESULTS: Over 5.7 years of follow-up, 1160 developed dementia and 552 Alzheimer's disease (AD). Apathy prevalence was 34.1% and more than three times higher in those with depression. Apathy was not associated with dementia risk among cognitively normal or non-depressed individuals. In contrast, among individuals with depression and mild cognitive impairment (MCI), apathy predicted a higher risk of dementia (hazard ratio [HR] 1.62) and AD (HR 1.74).
DISCUSSION: Apathy is associated with increased dementia risk only in older adults with MCI and depression. Findings highlight the need to incorporate affective symptom monitoring into dementia risk assessment and intervention.
HIGHLIGHTS: Harmonized data from 10 population-based cohorts across six continents were used. Apathy predicted dementia only in older adults with both depression and mild cognitive impairment. No association was found in non-depressed or cognitively normal individuals. Monitoring progression of affective symptoms may aid dementia risk stratification.