Journal of pediatric gastroenterology and nutrition · 2013
C-ANCA/proteinase 3-positive colitis in children: a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation?
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Van Biervliet Stephanie, Bonroy Carolien, Vande Velde Saskia, De Bruyne Ruth, Van Winckel Myriam, Peeters Harald, Delanghe Joris, Stove Veronique, De Vos Martine
Аннотация
AIM: Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context.
METHODS: Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype.
RESULTS: The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P < 0.05). None had vasculitis features at diagnosis nor during follow-up.
CONCLUSIONS: This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.
METHODS: Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype.
RESULTS: The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P < 0.05). None had vasculitis features at diagnosis nor during follow-up.
CONCLUSIONS: This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.