AJNR. American journal of neuroradiology · 2009
Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease.
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Henley S M D, Ridgway G R, Scahill R I, Klöppel S, Tabrizi S J, Fox N C, Kassubek J, EHDN Imaging Working Group
Аннотация
BACKGROUND AND PURPOSE: VBM is increasingly used in the study of neurodegeneration, and recently there has been interest in its potential as a biomarker. However, although it is largely "automated," VBM is rarely implemented consistently across studies, and changing user-specified options can alter the results in a way similar to the very biologic differences under investigation.
MATERIALS AND METHODS: This work uses data from patients with HD to demonstrate the effects of several user-specified VBM parameters and analyses: type and level of statistical correction, modulation, smoothing kernel size, adjustment for brain size, subgroup analysis, and software version.
RESULTS: The results demonstrate that changing these options can alter results in a way similar to the biologic differences under investigation.
CONCLUSIONS: If VBM is to be useful clinically or considered for use as a biomarker, there is a need for greater recognition of these issues and more uniformity in its application for the method to be both reproducible and valid.
MATERIALS AND METHODS: This work uses data from patients with HD to demonstrate the effects of several user-specified VBM parameters and analyses: type and level of statistical correction, modulation, smoothing kernel size, adjustment for brain size, subgroup analysis, and software version.
RESULTS: The results demonstrate that changing these options can alter results in a way similar to the biologic differences under investigation.
CONCLUSIONS: If VBM is to be useful clinically or considered for use as a biomarker, there is a need for greater recognition of these issues and more uniformity in its application for the method to be both reproducible and valid.