The Journal of antimicrobial chemotherapy · 2017
Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Brice Josephine, Sylla Mariam, Sayon Sophie, Telly Fatoumata, Bocar-Fofana Djeneba, Murphy Robert, Lambert-Niclot Sidonie, Todesco Eve, Grude Maxime, Barin Francis, Diallo Souleymane, Pillay Deenan, Derache Anne, Calvez Vincent, Marcelin Anne-Geneviève, Maiga Almoustapha Issiaka
Аннотация
BACKGROUND: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure.
OBJECTIVES: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children.
METHODS: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA.
RESULTS: Among the children studied, the median total HIV DNA level was 445 copies/10 6 cells (IQR = 187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation ( P = 0.01). Overall, eight HIV-1 seroreversions were identified.
CONCLUSIONS: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
OBJECTIVES: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children.
METHODS: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA.
RESULTS: Among the children studied, the median total HIV DNA level was 445 copies/10 6 cells (IQR = 187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation ( P = 0.01). Overall, eight HIV-1 seroreversions were identified.
CONCLUSIONS: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.