Archives of oral biology · 2014
Impairment of nasal airway under intermittent hypoxia during growth period in rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kuma Yoichiro, Usumi-Fujita Risa, Hosomichi Jun, Oishi Shuji, Maeda Hideyuki, Nagai Hisashi, Shimizu Yasuhiro, Kaneko Sawa, Shitano Chisa, Suzuki Jun-ichi, Yoshida Ken-ichi, Ono Takashi
Аннотация
OBJECTIVE: To clarify the influences of intermittent hypoxia (IH) on the growth and development of the midfacial area, including the nasal cavity, in growing rats.
DESIGN: Seven-week-old male Sprague-Dawley rats were divided into two groups: the experimental group (n=5), which was exposed to IH for 8h during light periods at a rate of 20 cycles/h (nadir, 4% O₂ to peak, 21% O₂ with 0% CO₂), and the control group (n=5), which was exposed to room air. After 3 weeks, the maxillofacial structures in both groups were evaluated with respect to the height, width, length, surface area, cross-sectional area, and volume of the nasal cavity using soft X-ray and micro-CT.
RESULTS: The experimental group showed a significantly smaller cross-sectional area and volume than did the control group. The surface area exhibited no significant differences between the two groups, although it tended to be smaller in the experimental group than in the control group. The nasal volume divided by the length of the tibia (for comparison with whole-body growth) was significantly smaller in the experimental group than in the control group.
CONCLUSIONS: These data suggest that IH exposure suppresses growth and development of the nasal cavity and may result in nasal breathing disturbance.
DESIGN: Seven-week-old male Sprague-Dawley rats were divided into two groups: the experimental group (n=5), which was exposed to IH for 8h during light periods at a rate of 20 cycles/h (nadir, 4% O₂ to peak, 21% O₂ with 0% CO₂), and the control group (n=5), which was exposed to room air. After 3 weeks, the maxillofacial structures in both groups were evaluated with respect to the height, width, length, surface area, cross-sectional area, and volume of the nasal cavity using soft X-ray and micro-CT.
RESULTS: The experimental group showed a significantly smaller cross-sectional area and volume than did the control group. The surface area exhibited no significant differences between the two groups, although it tended to be smaller in the experimental group than in the control group. The nasal volume divided by the length of the tibia (for comparison with whole-body growth) was significantly smaller in the experimental group than in the control group.
CONCLUSIONS: These data suggest that IH exposure suppresses growth and development of the nasal cavity and may result in nasal breathing disturbance.