Indian journal of pharmacology · 2012
Efficacy of oral miltefosine in visceral leishmaniasis in rural West Bengal, India.
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Patra Pradyumna, Guha Subhasish K, Maji Ardhendu Kumar, Saha Pabitra, Ganguly Swagata, Chakraborty Abhiram, Kundu Pratip K, Sarker Sachchidananda, Ray Krishnangshu
Аннотация
CONTEXT: Visceral leishmaniasis (VL), also known as Kala-azar (KA) is a public health problem of tropical and subtropical countries, which infects about 12 million people annually, out of which about 1.5 million are new cases. India contributes a major share of the global burden of VL. For many years leishmaniasis has been treated with pentavalent antimonials. Antimony resistance is a problem in India and in other different geographic areas of the world. Amphotericin B deoxycholate and pentamidine isethionate are effective by parenteral administration and associated with toxicities. The quest for an effective, orally administered, non-toxic and less expensive alternative resulted in the identification of miltefosine (hexadecylphosphocholine). In India, therapeutic efficacy of miltefosine in VL was assessed by many groups of scientists, mainly from Bihar and Uttar Pradesh. No such data is available from West Bengal.
AIMS: The present study was designed to observe the efficacy of miltefosine in VL in rural West Bengal.
MATERIALS AND METHODS: A total of 71 parasitologically proven VL patients participated in the study who received miltefosine in accordance with the National Vector Born Disease Control Programme (NVBDCP) of India and were followed up for the following one year.
RESULTS: The overall efficacy of the drug was 93% and no significant adverse side effects were observed during the study period.
CONCLUSIONS: The study concludes that miltefosine is effective, well tolerated, and easily administrable drug in the treatment of visceral leishmaniasis at the field levels.
AIMS: The present study was designed to observe the efficacy of miltefosine in VL in rural West Bengal.
MATERIALS AND METHODS: A total of 71 parasitologically proven VL patients participated in the study who received miltefosine in accordance with the National Vector Born Disease Control Programme (NVBDCP) of India and were followed up for the following one year.
RESULTS: The overall efficacy of the drug was 93% and no significant adverse side effects were observed during the study period.
CONCLUSIONS: The study concludes that miltefosine is effective, well tolerated, and easily administrable drug in the treatment of visceral leishmaniasis at the field levels.