Biomedica : revista del Instituto Nacional de Salud · 2008
[Preliminary evaluation of maggot (Diptera: Calliphoridae) therapy as a potential treatment for leishmaniasis ulcers].
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Arrivillaga Jazzmin, Rodríguez Jaime, Oviedo Milagros
Аннотация
INTRODUCTION: Maggot debridement therapy has been widely used for treating a variety of scarred-over soft-tissue wounds. Published accounts record several illnesses in which treatment with larval therapy has promoted injury healing in conjunction with infection by bacterial pathogens resistant to conventional antibiotics.
OBJECTIVE: An initial test of the maggot therapy was developed for cutaneous injuries produced by Leishmania amazonensis.
MATERIALS AND METHODS: An experimental design based on an animal model with three replicates in Mesocricetus aureatus (Rodentia: Muridae) was used to evaluate size variation lesion before and after after larval therapy with Lucilia sericata maggots . The criteria used for therapy evaluation were lesion size, maggot application time, and presence or absence of edema and secretions.
RESULTS: Effective scarring and wound healing was observed after therapy with L. sericata larvae, i.e. 80% to 100% lesion area reduction after 12 hours.
CONCLUSION: The preliminary results suggest that fly maggots of L. sericata have a potential use as natural medical and veterinary alternative therapy for the cutaneous leishmaniasis.
OBJECTIVE: An initial test of the maggot therapy was developed for cutaneous injuries produced by Leishmania amazonensis.
MATERIALS AND METHODS: An experimental design based on an animal model with three replicates in Mesocricetus aureatus (Rodentia: Muridae) was used to evaluate size variation lesion before and after after larval therapy with Lucilia sericata maggots . The criteria used for therapy evaluation were lesion size, maggot application time, and presence or absence of edema and secretions.
RESULTS: Effective scarring and wound healing was observed after therapy with L. sericata larvae, i.e. 80% to 100% lesion area reduction after 12 hours.
CONCLUSION: The preliminary results suggest that fly maggots of L. sericata have a potential use as natural medical and veterinary alternative therapy for the cutaneous leishmaniasis.