Immunity · 2018
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Filipello Fabia, Morini Raffaella, Corradini Irene, Zerbi Valerio, Canzi Alice, Michalski Bernadeta, Erreni Marco, Markicevic Marija, Starvaggi-Cucuzza Chiara, Otero Karel, Piccio Laura, Cignarella Francesca, Perrucci Fabio, Tamborini Matteo, Genua Marco, Rajendran Lawrence, Menna Elisabetta, Vetrano Stefania, Fahnestock Margaret, Paolicelli Rosa Chiara, Matteoli Michela
Аннотация
The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune receptor associated with a lethal form of early, progressive dementia, Nasu-Hakola disease, and with an increased risk of Alzheimer's disease. Microglial defects in phagocytosis of toxic aggregates or apoptotic membranes were proposed to be at the origin of the pathological processes in the presence of Trem2 inactivating mutations. Here, we show that TREM2 is essential for microglia-mediated synaptic refinement during the early stages of brain development. The absence of Trem2 resulted in impaired synapse elimination, accompanied by enhanced excitatory neurotransmission and reduced long-range functional connectivity. Trem2-/- mice displayed repetitive behavior and altered sociability. TREM2 protein levels were also negatively correlated with the severity of symptoms in humans affected by autism. These data unveil the role of TREM2 in neuronal circuit sculpting and provide the evidence for the receptor's involvement in neurodevelopmental diseases.