Experimental parasitology · 2018
First description of clonal lineage type II (genotype #1) of Toxoplasma gondii in abortion outbreak in goats.
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de Oliveira Júnior Mário Baltazar, de Almeida Jonatas Campos, de Melo Renata Pimentel Bandeira, de Barros Luiz Daniel, Garcia João Luis, Andrade Müller Ribeiro, Porto Wagnner José Nascimento, Regidor-Cerrillo Javier, Ortega-Mora Luis Miguel, Oliveira Andréa Alice da Fonseca, Mota Rinaldo Aparecido
Аннотация
The purpose of this study was to perform genotypic characterization and to evaluate the virulence of Toxoplasma gondii obtained from aborted fetuses in an abortion outbreak in goats from northeastern Brazil. Brain samples from 32 fetuses were submitted to mouse bioassay for T. gondii isolation. Two isolates were obtained and subjected to genotypic characterization. Isolate virulence was evaluated using murine model in different doses (from 105 to 101 tachyzoites/mL). In genotyping, both isolates were classified as clonal lineage type II (genotype #1 ToxoDB) and showed to be virulent for mice. This is the first description of genotype #1 in cases of goat abortion, showing the circulation of virulent T. gondii isolate producing reproductive disorders in pregnant goat.