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Войти в исследования Contact dermatitis · 2025
Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Simonsen Anne Birgitte, Rustemeyer Thomas, Hadzavdic Suzana Ljubojevicé, Spiewak Radoslaw, Fortina Anna Belloni, Gonçalo Margarida, Arnau Ana Maria Giménez, Planella-Fontanillas Nidia, Schuttelaar Marie L A, Dickel Heinrich, White Jonathan, Pónyai Györgyi, Wilkinson S Mark, Özkaya Esen, Dendooven Ella, Pustišek Nives, Johansen Jeanne Duus, Aerts Olivier, European Baseline Series (EBS) Working Party of the European Society of Contact Dermatitis (ESCD)
Аннотация
BACKGROUND: Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.
OBJECTIVES: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.
MATERIALS AND METHODS: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.
RESULTS: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.
CONCLUSION: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.
OBJECTIVES: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.
MATERIALS AND METHODS: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.
RESULTS: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.
CONCLUSION: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.