BMJ open · 2021
SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from May to October 2020 in German secondary schools.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kirsten Carolin, Unrath Manja, Lück Christian, Dalpke Alexander H, Berner Reinhard, Armann Jakob
Аннотация
OBJECTIVE: To quantify the number of SARS-CoV-2 infections in secondary schools after their reopening in May 2020.
DESIGN: Repeated SARS-CoV-2 seroprevalence study after the reopening of schools and 4 months later.
SETTING: Secondary school in Dresden, Germany.
PARTICIPANTS: 1538 students grades 8-12 and 507 teachers from 13 schools.
INTERVENTIONS: Serial blood sampling and SARS-CoV-2 IgG antibody assessment.
PRIMARY AND SECONDARY OUTCOME MEASURE: Seroprevalence of SARS-CoV-2 antibodies in study population. Number of undetected cases.
RESULTS: 1538 students and 507 teachers were initially enrolled, and 1334 students and 445 teachers completed both study visits. The seroprevalence for SARS-CoV-2 antibodies was 0.6% in May/June and the same in September/October. Even in schools with reported COVID-19 cases before the lockdown of 13 March, no clusters could be identified. Of 12 persons with positive serology five had a known history of confirmed COVID-19; 23 out of 24 participants with a household history of COVID-91 were seronegative.
CONCLUSIONS: Schools do not play a crucial role in driving the SARS-CoV-2 pandemic in a low-prevalence setting. Transmission in families occurs very infrequently, and the number of unreported cases is low in this age group. These observations do not support school closures as a strategy fighting the pandemic in a low-prevalence setting.
TRIAL REGISTRATION NUMBER: DRKS00022455.
DESIGN: Repeated SARS-CoV-2 seroprevalence study after the reopening of schools and 4 months later.
SETTING: Secondary school in Dresden, Germany.
PARTICIPANTS: 1538 students grades 8-12 and 507 teachers from 13 schools.
INTERVENTIONS: Serial blood sampling and SARS-CoV-2 IgG antibody assessment.
PRIMARY AND SECONDARY OUTCOME MEASURE: Seroprevalence of SARS-CoV-2 antibodies in study population. Number of undetected cases.
RESULTS: 1538 students and 507 teachers were initially enrolled, and 1334 students and 445 teachers completed both study visits. The seroprevalence for SARS-CoV-2 antibodies was 0.6% in May/June and the same in September/October. Even in schools with reported COVID-19 cases before the lockdown of 13 March, no clusters could be identified. Of 12 persons with positive serology five had a known history of confirmed COVID-19; 23 out of 24 participants with a household history of COVID-91 were seronegative.
CONCLUSIONS: Schools do not play a crucial role in driving the SARS-CoV-2 pandemic in a low-prevalence setting. Transmission in families occurs very infrequently, and the number of unreported cases is low in this age group. These observations do not support school closures as a strategy fighting the pandemic in a low-prevalence setting.
TRIAL REGISTRATION NUMBER: DRKS00022455.