Effect of a toothpaste containing amyloglucosidase and glucose oxidase on recurrent aphthous ulcers.

The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40% lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32%) and experimental groups (about 66%). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.