Thyroid Hormone Treatment for Hypercholesterolemia in Euthyroid Patients: Results From a European Survey of Thyroid Specialists.
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Galofré Juan C, Díez Juan J, Attanasio Roberto, Nagy Endre V, Bednarczuk Tomasz, Papini Enrico, Žarković Miloš, Negro Roberto, Perros Petros, Akarsu Ersin, Alevizaki Maria, Ayvaz Göksun, Berta Eszter, Beleslin Biljana Nedeljković, Bodor Miklos, Borissova Anna Maria, Boyanov Mihail, Burlacu Maria-Cristina, Ćirić Jasmina, Fadeyev Valentin, Field Benjamin C T, Führer Dagmar, Jan Jiskra, Kopp Peter, Krebs Michael, Kršek Michal, Lazúrová Ivica, Luchytskiy Vitaliy, Puga Francisca Marques, McGowan Anne, Miguel Melo, Metso Saara, Moran Carla, Morgunova Tatyana, Niculescu Dan Alexandru, Perić Božidar, Planck Tereza, Robenshtok Eyal, Rosselet Patrick Olivier, Ruchala Marek, Shepelkevich Alla, Tronko Mykola, Unuane David, Vardarli Irfan, Visser W Edward, Vryonidou Andromachi, Younes Younes R, Hegedüs Laszlo
Аннотация
DESIGN: Data were derived from the THESIS (Treatment of Hypothyroidism in Europe by Specialists) project that surveyed TH use. Univariable and multivariable analyses were used to explore associations.
RESULTS: Out of 17,232 invitations, 5695 (33.0%) valid responses were received, and of these, 328 (5.8%) stated that TH are indicated in euthyroid patients with severe hypercholesterolemia. Univariable analyses disclosed significant differences and associations: (a) more non-endocrinologists (8.9%) than endocrinologist (5.4%) used TH (p < 0.001), (b) the number of hypothyroid patients treated per year was inversely related to use of TH (p = 0.024), (c) members of international endocrine/thyroid societies were more likely to use TH than non-members (p < 0.001), (d) significant variations by country and geographical region (p < 0.001), and (e) inverse relationship between gross national income per capita (GNIPC) and TH use (p < 0.001). Multivariable analyses yielded significant associations between use of TH, and male gender, specialty and GNIPC (p < 0.001).
CONCLUSIONS: This study suggests that a small but noteworthy minority of European thyroid specialists may be using TH to treat of severe hypercholesterolemia in euthyroid patients. If confirmed, this finding highlights the importance of raising awareness among thyroid specialists, professional societies, and healthcare providers to ensure adherence to evidence-based practices.