Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies.
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Simões Cunha Mafalda, Amaral Rita, Pereira Ana Margarida, Almeida Rute, Alves-Correia Magna, Loureiro Cláudia Chaves, Lopes Cristina, Carvalho Joana, Ribeiro Carmelita, Vidal Carmen, Antolín-Amérigo Dario, Pinto Diana, Ferreira-Magalhães Manuel, Vasconcelos Maria João, Lozoya Carlos, Santos Natacha, Cardia Francisca, Taborda-Barata Luís, Ferreira Rosário, Morais Silva Pedro, Ferreira Tania Monteiro, Câmara Raquel, Silva Eurico, Bordalo Diana, Guimarães Cristina, Calix Maria José, da Silva Sofia, Marques Maria Luís, Morete Ana, Nunes Carlos, Vieira Cláudia, Páscoa Rosália, Alves Adelaide, Marques José Varanda, Reis Bruno, Monteiro Luís, Monteiro Rosário, Cepa Margarida, Valentim Bruno, Coelho Daniela Sousa, Fernandes Sara, Meireles Patrícia, Aguiar Margarida Abreu, Mourão Ana Rita, Fonseca Joao A, Jácome Cristina
Аннотация
METHODS: This is a secondary analysis of the INSPIRERS studies. A total of 614 adolescents and adults with persistent asthma (32.6±16.9 years, 64.7% female) were recruited from 30 primary care centres and 32 allergy, pulmonology and paediatric clinics. Demographic and clinical characteristics, HADS and EQ-5D were collected. A score ≥8 on Hospital Anxiety and Depression Scale-Anxiety/Hospital Anxiety and Depression Scale-Depression or a positive answer to EQ-5D item 5 indicated the presence of these symptoms. Agreement was determined by Cohen's kappa. Two multivariable logistic regressions were built.
RESULTS: According to HADS, 36% of the participants had symptoms of anxiety and 12% of depression. According to EQ-5D, 36% of the participants had anxiety/depression. The agreement between questionnaires in identifying anxiety/depression was moderate (k=0.55, 95% CI 0.48 to 0.62). Late asthma diagnosis, comorbidities and female gender were predictors of anxiety/depression, while better asthma control, health-related quality of life and perception of health were associated with lower odds for anxiety/depression.
CONCLUSION: At least 1/3 of the patients with persistent asthma experience symptoms of anxiety/depression, showing the relevance of screening these disorders in patients with asthma. EQ-5D and HADS questionnaires showed a moderate agreement in the identification of anxiety/depression symptoms. The identified associated factors need to be further investigated in long-term studies.