Minerva medica · 2022
Nutrition program, physical activity and gut microbiota modulation: a randomized controlled trial to promote a healthy lifestyle in students with vitamin D3 deficiency.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tokarchuk Anastasiia, Abenavoli Ludovico, Kobyliak Nazarii, Khomenko Maria, Revun Mariia, Dolgaia Nadiia, Molochek Nataliia, Tsyryuk Olena, Garnytska Anna, Konakh Valentyna, Pellicano Rinaldo, Fagoonee Sharmila, Ostapchenko Liudmyla, Falalyeyeva Tetyana
Аннотация
BACKGROUND: University students are a high-risk group for stress, consumption of junk food and significant weight gain over a short period. Inadequate vitamin D intake has been linked to many health issues, including chronic headache, apathy, aggression and depression. Furthermore, vitamin D deficiency led to dysbiosis of the gut microbiota. The purpose of our study was to estimate the effect of 90-days healthy lifestyle programs along with gut microbiota modulation in university students with vitamin D<inf>3</inf> deficiency.
METHODS: In this randomized controlled trial, 130 students (18-25 years old) with vitamin D deficiency were recruited. Both the standard care group (N.=65) and the intervention group (N.=65) received a 3-months course of individually selected nutrition program and physical activity (8000-10,000 steps daily). The intervention group received an additional treatment with synbiotic Acidolac and vitamin D<inf>3</inf> for 3 months. The psycho-emotional status of the participants was assessed by a validated questionnaire that examined situational anxiety. In all students, blood pressure, anthropometric variables, as well as laboratory metabolic parameters, were recorded.
RESULTS: In both groups, vitamin D<inf>3</inf> deficiency was associated with instability and lability of mental processes, mood swings, bad sleep, high rates of stuck and agitation for any problem. Combined therapy (diet, physical activity and synbiotic) induced a significant improvement in the psycho-emotional state of students. The 90-days therapy vitamin D<inf>3</inf> increased the level of vitamin D<inf>3</inf> in serum in the intervention group. Lastly, we observed a decrease in the body weight, body mass index, waist circumference and fatty mass, only in students included in the interventional group.
CONCLUSIONS: Nutrition program, physical activity, vitamin D<inf>3</inf> intake and gut microbiota modulation led to both the improvement in vitamin D levels in serum and emotional harmonization.
METHODS: In this randomized controlled trial, 130 students (18-25 years old) with vitamin D deficiency were recruited. Both the standard care group (N.=65) and the intervention group (N.=65) received a 3-months course of individually selected nutrition program and physical activity (8000-10,000 steps daily). The intervention group received an additional treatment with synbiotic Acidolac and vitamin D<inf>3</inf> for 3 months. The psycho-emotional status of the participants was assessed by a validated questionnaire that examined situational anxiety. In all students, blood pressure, anthropometric variables, as well as laboratory metabolic parameters, were recorded.
RESULTS: In both groups, vitamin D<inf>3</inf> deficiency was associated with instability and lability of mental processes, mood swings, bad sleep, high rates of stuck and agitation for any problem. Combined therapy (diet, physical activity and synbiotic) induced a significant improvement in the psycho-emotional state of students. The 90-days therapy vitamin D<inf>3</inf> increased the level of vitamin D<inf>3</inf> in serum in the intervention group. Lastly, we observed a decrease in the body weight, body mass index, waist circumference and fatty mass, only in students included in the interventional group.
CONCLUSIONS: Nutrition program, physical activity, vitamin D<inf>3</inf> intake and gut microbiota modulation led to both the improvement in vitamin D levels in serum and emotional harmonization.