Biological psychiatry · 2003
Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Smoller Jordan W, Rosenbaum Jerrold F, Biederman Joseph, Kennedy John, Dai Daisy, Racette Stephanie R, Laird Nan M, Kagan Jerome, Snidman Nancy, Hirshfeld-Becker Dina, Tsuang Ming T, Sklar Pamela B, Slaugenhaupt Susan A
Аннотация
BACKGROUND: Behavioral inhibition to the unfamiliar (BI), a heritable temperamental profile involving an avoidant response to novel situations, may be an intermediate phenotype in the development of anxiety disorders. Corticotropin-releasing hormone (CRH) is a key mediator of the stress response through its effects on the hypothalamic-pituitary-adrenal axis and limbic brain systems. Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype.
METHODS: We genotyped a marker tightly linked to the CRH locus in 85 families of children who underwent laboratory-based behavioral assessments of BI and performed family-based association analyses.
RESULTS: We observed an association between an allele of the CRH-linked locus and BI (p =.015). Among offspring of parents with panic disorder, this association was particularly marked (p =.0009). We further demonstrate linkage disequilibrium between this marker and single nucleotide polymorphisms encompassing the CRH gene.
CONCLUSIONS: These results are consistent with the possibility that variants in the CRH gene are associated with anxiety proneness.
METHODS: We genotyped a marker tightly linked to the CRH locus in 85 families of children who underwent laboratory-based behavioral assessments of BI and performed family-based association analyses.
RESULTS: We observed an association between an allele of the CRH-linked locus and BI (p =.015). Among offspring of parents with panic disorder, this association was particularly marked (p =.0009). We further demonstrate linkage disequilibrium between this marker and single nucleotide polymorphisms encompassing the CRH gene.
CONCLUSIONS: These results are consistent with the possibility that variants in the CRH gene are associated with anxiety proneness.
Предметные рубрики MeSH
Anxiety DisordersChildChild, PreschoolChromosome MappingCorticotropin-Releasing HormoneFamily HealthFemaleGene FrequencyGenetic MarkersGenotypeHumansInhibition, PsychologicalLinkage DisequilibriumMaleNeuropsychological TestsPhenotypePolymorphism, Single NucleotideRNA, MessengerReverse Transcriptase Polymerase Chain Reaction