Deutsche medizinische Wochenschrift (1946) · 2018
[Simvastatin-Induced Myopathy after Dose Increase].
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Kandzia Imke, Kowar Michael, Frackowiak Monika, Jacobs Andreas H
Аннотация
HISTORY AND CLINICAL FINDINGS: We present a 86-year-old patient who suffered from progressive weakness in his right leg. Due to a hypercholesterinemia he had received Simvastatin for a few years. Because of higher cholesterine levels the dosis had been increased from 40 to 80 mg 6 months ago.
INVESTIGATIONS AND DIAGNOSIS: We saw elevated levels of creatinine kinase and creatinine. In the EMG, a neuromuscular impairment was detected. In context with the medical history we could make the diagnosis of a statin-induced myopathy with rhabdomyolysis.
TREATMENT AND COURSE: After stopping the medication with statin and under liquid substitution, creatinine kinase and creatinine levels dropped. After therapy the weakness of the leg was totally recurrent.
CONCLUSION: In case of unclear neurological symptoms and under therapy with statins, a myopathy should be considered.
INVESTIGATIONS AND DIAGNOSIS: We saw elevated levels of creatinine kinase and creatinine. In the EMG, a neuromuscular impairment was detected. In context with the medical history we could make the diagnosis of a statin-induced myopathy with rhabdomyolysis.
TREATMENT AND COURSE: After stopping the medication with statin and under liquid substitution, creatinine kinase and creatinine levels dropped. After therapy the weakness of the leg was totally recurrent.
CONCLUSION: In case of unclear neurological symptoms and under therapy with statins, a myopathy should be considered.