Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts.
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Jiang Xueyan, Hu Xiaochen, Daamen Marcel, Wang Xiaoqi, Fan Chunqiu, Meiberth Dix, Spottke Annika, Roeske Sandra, Fliessbach Klaus, Spruth Eike Jakob, Altenstein Slawek, Lohse Andrea, Hansen Niels, Glanz Wenzel, Incesoy Enise I, Dobisch Laura, Janowitz Daniel, Rauchmann Boris-Stephan, Ramirez Alfredo, Kilimann Ingo, Munk Matthias H, Wang Xiao, Schneider Luisa-Sophie, Gabelin Tatjana, Roy Nina, Wolfsgruber Steffen, Kleineidam Luca, Hetzer Stefan, Dechent Peter, Ewers Michael, Scheffler Klaus, Amthauer Holger, Buchert Ralph, Essler Markus, Drzezga Alexander, Rominger Axel, Krause Bernd J, Reimold Matthias, Priller Josef, Schneider Anja, Wiltfang Jens, Buerger Katharina, Perneczky Robert, Teipel Stefan, Laske Christoph, Peters Oliver, Düzel Emrah, Wagner Michael, Jiang Jiehui, Jessen Frank, Boecker Henning, Han Ying
Аннотация
METHODS: Cross-sectional resting-state functional magnetic resonance imaging connectivity (FC) and amyloid-positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.
RESULTS: Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD-plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC-amyloid associations across cohorts.
DISCUSSION: Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture-specific features to enrich preclinical Alzheimer's disease in non-Western populations.
HIGHLIGHTS: Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross-cultural harmonization of SCD regarding Alzheimer's disease pathology is required.