The American journal of tropical medicine and hygiene · 2007
Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution?
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Morizot Gloria, Delgiudice Pascal, Caumes Eric, Laffitte Emmanuel, Marty Pierre, Dupuy Alain, Sarfati Claudine, Hadj-Rabia Smain, Darie Herve, LE Guern Anne-Sophie, Salah Afif Ben, Pratlong Francine, Dedet Jean-Pierre, Grögl Max, Buffet Pierre A
Аннотация
The efficacy of fluconazole was evaluated in 35 travelers with parasitologically proven imported Old World cutaneous leishmaniasis (CL). Leishmania major (mainly MON-25) was identified in 15 patients and strongly suspected given the transmission area in 12 of these patients. Daily oral fluconazole (200 mg/day for adults and 2.5 mg/kg/day for children) was prescribed for six weeks. Outcome definition was based on re-epithelialization rate at day 50. Of the 27 L. major-infected patients, 12 (44.4%) were cured. This cure rate is similar to the placebo cure rate from trials in L. major CL in which, as in the present report, the definition of outcome relied exclusively on re-epithelialization. These data question the assumption that oral fluconazole is consistently effective for treatment of CL caused by L. major.